منابع مشابه
Inhibiting myostatin reverses muscle fibrosis through apoptosis
160 words Text: 3,690 words Condensed Title: Myostatin Inhibition Reverses Fibrosis © 2012. Published by The Company of Biologists Ltd. Jo ur na l o f C el l S ci en ce A cc ep te d m an us cr ip t JCS online publication date 8 June 2012 Myostatin Inhibition Reverses Fibrosis
متن کاملBrain Serotonin, Carbohydrate-craving, obesity and depression.
Serotonin-releasing brain neurons are unique in that the amount of neurotransmitter they release is normally controlled by food intake: Carbohydrate consumption--acting via insulin secretion and the "plasma tryptophan ratio"--increases serotonin release; protein intake lacks this effect. This ability of neurons to couple neuronal signaling properties to food consumption is a link in the feedbac...
متن کاملAutonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension.
Impaired nitric oxide (NO) vasodilation (endothelial dysfunction) is associated with obesity and thought to be a factor in the development of hypertension. We previously found that NO synthesis inhibition had similar pressor effects in obese hypertensives compared with healthy control during autonomic blockade, suggesting that impaired NO vasodilation is secondary to sympathetic activation. We ...
متن کاملCaloric restriction reverses obesity-induced mammary gland inflammation in mice.
Obesity is a risk factor for the development of hormone receptor-positive breast cancer in postmenopausal women. Estrogen synthesis is catalyzed by aromatase. Recently, we identified an obesity→inflammation→aromatase axis in mouse models and women. In mouse models of obesity, inflammatory foci characterized by crown-like structures (CLS) consisting of dead adipocytes encircled by macrophages we...
متن کاملBrown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice.
Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted BAT from C57/BL6 mice into the dorsal subcutaneous region of age- and sex-matched leptin deficient O...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2015
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4549